更令人振奋的是，采用UNG抑制剂或腺相关病毒(adeno-associated virus, AAV)载体递送尿嘧啶-DNA糖基化酶抑制剂(UGI)的治疗方案，成功将野生型HSV-1感染小鼠从死亡边缘拉回。 这些发现不仅绘制出HSV-1与宿主APOBEC1博弈的分子图谱，更开辟了对抗病毒性脑炎的新战线——靶 ...

这篇综述系统梳理了眼科基因治疗的最新进展，重点探讨了病毒/非病毒载体（AAV/CRISPR-Cas9）在遗传性视网膜疾病（IRDs ...

Infection with herpes simplex virus type 1 (HSV-1), the virus that causes cold sores, is associated with the development of Alzheimer’s disease – that’s the conclusion of a new case-control ...

More information: Association between herpes simplex virus type 1 and the risk of Alzheimer's disease: a retrospective case– control study, BMJ Open (2025). DOI: 10.1136/bmjopen-2024-093946 ...

The Centers for Disease Control and Prevention (CDC) estimates that about 45 million people in the United States have genital HSV, with up to a half-million new cases identified each year.

TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the ...

According to the World Health Organization, about 3.8 billion people under age 50 have HSV-1. Around 520 million people ages 15 to 49 have HSV-2. According to the World Health Organization ...

Joyce Siette receives funding from the National Health and Medical Research Council on a Targeted Call for Research on cultural, ethnic and linguistic diversity in dementia research. A new study ...

and the University of Washington’s Department of Medicine (UW Medicine) has added to the mounting evidence, finding an association between herpes simplex virus type 1 (HSV-1) and the risk of ...

CRISPR Therapeutics AG ... CAR T cell therapies, in vivo, and type 1 diabetes, as well as develops investigational CAR T programs, including an autologous, gene-edited CAR T program targeting ...

The herpes simplex virus 1 uracil-DNA glycosylase counters host APOBEC1 to evade genome editing and to enable viral replication that promotes encephalitis in mice. Epstein-Barr virus (EBV ...