In this article we give an overview of RNA-based HPV diagnostics and the role of E6/E7 mRNA detection as a predictive marker for the development of cervical carcinoma. HPV E6/E7 mRNA testing for ...

Gen-Probe is currently developing the APTIMA HPV Assay, targeting E6/E7 mRNA from 14 carcinogenic HPV genotypes. A prototype of this assay was evaluated recently in 536 women with histological ...

Objectives To assess the performance of a 5-type human papillomavirus (HPV) messenger RNA (mRNA) test in primary screening within the framework of the Norwegian population-based screening programme.

在精准医疗领域持续深耕的科蒂亚生物，作为国内分子病理诊断领域的“探路者”，凭借其自主研发的QuantiMAT专利技术平台，以及基于该平台开发的、结合b-DNA信号放大技术的HPV E6/E7 mRNA检测试剂盒，已成为国内HPV E6/E7 mRNA检测领域的行业标杆。作为一家集研发 ...

Methods Four electronic databases were searched to find studies that met the following inclusion criteria: i) performed in humans; ii) were cohort, case-control or cross-sectional; iii) assessed the ...

为解决评估药物与 HPV E6/E7 蛋白相互作用的难题（E6/E7 定位于细胞核，需跨膜探针实时监测），研究人员开发核膜通透锌离子荧光探针 NTAD-N2。体外 / 内实验显示双硫仑和依布硒仑可诱导 Zn2+释放，且机制与 E6/E7 降解相关。该研究为 HPV 相关肿瘤治疗提供新策略。

本综述聚焦 HPV 驱动的癌症（如宫颈癌），探讨 CRISPR/Cas9 基因编辑技术在靶向抑制 HPV E6、E7 癌基因，恢复抑癌基因 p53、pRb 功能中的潜力，分析其机制、疗效、挑战及与免疫疗法等联合应用前景，为 HPV 相关癌症精准治疗提供新思路。 人乳头瘤病毒（HPV ...

宫颈癌，这个曾经被认为是可以彻底消灭的癌症，如今却依然在全球范围内造成了巨大的威胁。根据最新数据，2022年全球新确诊宫颈癌病例达661,021例，近350,000人因此失去生命。更令人担忧的是，宫颈癌与高危型人乳头瘤病毒（HPV）的关系密不可分，几乎所有宫颈癌病例都与HPV的持续感染有关。那么，面对这一严峻现状，我们应该如何应对？疫苗是否真的能成为我们的“护身符”？

This eBook explores how government contractors can achieve enterprise-wide alignment and operational excellence by implementing a centralized contract intelligence platform. With tailored insights ...