After entering an immune cell, HIV's single-stranded RNA genome is reverse-transcribed into double-stranded DNA, which is how our cells store genetic information. The virus' genome is incorporated ...

One of the key findings was the discovery of previously unrecognized elements in HIV-1 RNA called ... site" in the viral genome. This frameshift site is essential for the virus to produce the ...

What about viruses? Would you consider them living or nonliving? Let’s look closely at the life cycle of the human immunodeficiency virus (HIV) – the virus that causes AIDS – to find out. This ...

To become infectious, HIV has to undergo a maturation process, which involves a rearrangement of the matrix proteins (red).

Smuggling its genome ... for HIV to infect its host, but entering the cell’s control center is no easy feat. Molecules must pass through tightly-regulated nuclear pores on the backs of specialized ...

We can become infected with a small number of virus particles ... 42% of the human genome (Lander et al. 2001) and can move within the genome via an RNA intermediate. Like retroviruses ...

such as HIV, encode additional trans-regulating factors or contain cis-regulating elements, thereby influencing the type and amount of transcribed RNA. The whole viral genome is transcribed and ...

However, this treatment does not result in the total eradication of HIV. Rather, the virus is thought to remain ... molecular nature of the latent viral genome. HIV replication is linked to ...

To find out, Lai mixed the plasmids with HIV proteins that transcribe the viral genome and saw that they indeed formed infectious virions, albeit at a low rate. 3 “The idea that even if you have ...

Supercomputer simulations have revealed how changes in the shape of the HIV ... virus's infection cycle. HIV inserts its genes into the host cell's nucleus in an unusual way. It doesn't import its ...