The proteins HIF-1a and CD24 have both been implicated in the aggressive characteristics of hypoxic cancers. A new study shows that HIF-1a drives CD24 overexpression, ... MD, PhD, director of the ...

WYNNEWOOD, PA--June 3, 2015--a study led by Ellen Heber-Katz, PhD, of the Lankenau Institute for Medical Research (LIMR), part of Main Line Health (MLH), shows that a primordial form of energy ...

"We discovered that the HIF-1a pathway--an oxygen regulatory pathway predominantly used early in evolution but still used during embryonic development--can act to trigger healthy regrowth of lost ...

Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a ...

Hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are α-ketoglutarate (αKG)-dependent dioxygenases that function as cellular oxygen sensors. However, PHD activity also depends on factors ...

AKB-4924 stabilizes HIF-1a by inhibiting HIFprolyl hydroxylases (PHD), particularly PHD-2. Pre-clinical studies have shown AKB-4924 stimulates innate immunity and thus promotes wound healing.

Dr. Ahmad has indentified functional differences between HIF-1a and HIF-2a in cells of the pulmonary vasculature. He has found that HIF-2a promotes endothelial proliferation independent of HIF-1a. He ...

As long as HIF-1a was silenced, fibrosis was reduced in the oxygen-deprived kidney. This demonstrated that HIF-1 promoted the fibrotic process under reduced oxygen conditions.

By temporarily elevating HIF-1a, the drug shifts a tissue's metabolic state toward one used in early fetal development, ... PhD, and Kamila Bedelbaeva, MD, PhD.

Of the inducer of class III beta tubulin (TUBB3), recent report showed that HIF-1a (hypoxia inducible factor-1alpha), one of contributor to chemoresistance in gastric cancer. And HIF-1a was suppressed ...

Additionally, endothelial cells with activated HIF-1a generate pro-inflammatory signals or compounds, which means inflammatory cells are also activated; This is important and useful in normal ...

Akebia Therapeutics has spun out a new company, Aerpio Therapeutics, to continue the development of its small molecule Tie-2 activator and HIF-1α stabilizer programs for multiple diseases.