Glycome is composed of all the glycosylated and glycan molecules which produced through the biosynthetic process of bioglycosylation. We now know that all types of cells including prokaryotes (e.g., ...

陈兴/戴鹏团队于2025年2月7日在Nature Communications上在线发表题为“Mutant glycosidases for labeling sialoglycans with high specificity and affinity”的研究论文，该工作报道了一类基于糖基水解酶突变策略的唾液酸化糖质亲和标记工具 GRABs。 亲和标记（Affinity ...

Lysosomes house over 60 hydrolases, including proteases, lipases, nucleases, and glycosidases (2). Key proteolytic enzymes include cathepsins (e.g., cathepsin B, D, and L), which degrade proteins into ...

Hydrolases are enzymes that catalyze the cleavage of a covalent bond using water. Types of hydrolase include esterases, such as phosphatases, that act on ester bonds, and proteases or peptidases ...

Laboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstr. 6/III, A-8010 Graz, Austria ...

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ...

In some cases, such as glycosidases, the substrate molecule also changes shape slightly as it enters the active site. The active site continues to change until the substrate is completely bound, at ...