This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative phosphorylation and reducing glycolysis. The clinical relevance of PDK1 Y163 ...

This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative phosphorylation and reducing glycolysis. The clinical relevance of PDK1 Y163 ...

USP7 与 PDK1 相互作用：利用酵母双杂交系统筛选出 USP7 的相互作用蛋白 3 - 磷酸肌醇依赖性蛋白激酶 - 1（PDK1），并通过免疫共沉淀实验在多种细胞系中验证了二者的相互作用，还确定了 PDK1 的 C 末端含 PH 结构域是与 USP7 结合的区域。 USP7 去泛素化并稳定 PDK1 ...

Key metabolic adaptations, such as enhanced glycolysis, fatty acid oxidation, and glutamine metabolism ... HIF also inhibits mitochondrial oxidative phosphorylation (OXPHOS) by activating pyruvate ...

Glycolysis is an ancient metabolic activity. It consists of a set of reactions that convert glucose into energy. This central process allows cells to grow, divide, and stay alive. It has accompanied ...

Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P. R. China These authors contributed equally to this work. Department of Radiology, The Third ...

In normal human cells within the microenvironment, glucose molecules are metabolized to pyruvate through glycolysis. Pyruvate can undergo further oxidation in the mitochondria through oxidative ...

Department of Pharmacy, the Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, China Research Center of Integration of Traditional Chinese and Western Medicine, Wannan Medical College, ...

体外实验证实，过表达ETV4（oe-ETV4）使PKM2二聚体含量增加852%，促进葡萄糖摄取（GLU）和乳酸（LD）生成（P<0.01），同时上调PDK1、LDHA等糖酵解相关蛋白。ChIP实验验证ETV4可直接结合PKM2启动子的两个特定区域。 ??ETV4通过PKM2介导的糖酵解促进铁死亡抵抗?? 使用铁死亡 ...

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