In addition, we examined the molecular signaling pathways activated in the hippocampus of prenatally stressed rats, characterized by persistently elevated glucocorticoid levels in adulthood.

Thus, glucocorticoid receptors mediate long-term memory formation by recruiting the CaMKIIα-BDNF-CREB–dependent neural plasticity pathways. You have full access to this article via your ...

Inflammation is a reflexive response to infection, the binding of antibodies to antigens within the body, mechanical irritation, or injury. 1 Microbes that breach epithelial barriers, for instance ...

but they get there through different pathways," McNally said. The findings suggest that weekly glucocorticoid steroid treatment is beneficial for improving muscle health and performance and is ...

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients.

The median cumulative glucocorticoid dose at 52 weeks was ... 6 receptor α and efficiently blocks the interleukin-6 pathway. We performed the Sarilumab in Patients with Polymyalgia Rheumatica ...

cortisol precursors are shifted to a pathway of increased adrenal androgen production. Glucocorticoid replacement is given to prevent adrenal insufficiency and to suppress excess adrenal androgen ...

Glucocorticoids are the standard treatment ... in earlier observations in a hybrid human/mouse model that two separate pathways are involved in disease pathogenesis, the Th1 pathway and the ...

Aging Health. 2012;8(5):471-477. Osteoporosis associated with chronic glucocorticoid therapy appears to be an important medical problem, which may often be underestimated. Glucocorticosteroids ...

“The AMP-activated protein kinase pathway might represent one of the mediators of glucocorticoid and metformin interaction. Metformin might interact with glucocorticoid metabolism via 11-beta ...

Once it reaches the fat stem cell, Adamts1 transmits its message through a set of intracellular signals that overlap with the cells' glucocorticoid response pathway. A cell-signaling molecule ...

today presented preclinical data from the company’s glucocorticoid receptor (GR) antagonist and CD73 inhibitor programs in five poster presentations during the ongoing American Association for ...