Understanding the benefits and downsides of using a glucocorticoid-based treatment regimen for AAV is key to positive outcomes. Glucocorticoids are a key therapy in the management of antineutrophil ...

Inhibition of the c‐Jun N‐terminal kinase (JNK) pathway by glucocorticoids (GCs) results in AP‐1 repression. GC antagonism of AP‐1 relies mainly on the transrepression function of the GC receptor (GR) ...

BMDMs, bone marrow-derived macrophage; DXM, dexamethosone; GCs, glucocorticoids; GR, GC receptor; LPS, lipopolysaccharide; MTX, methotrexate; STAT1, signal transducer and activator of transcription.

In general, glucocorticoids participate the vascular remodeling of aortic dissection via the p38 MAPK-HSP27 pathway mediated by TNF-sRII. Increasing researches suggest that inflammatory response is ...

This study aimed to evaluate the association of the glucocorticoid pathway polymorphisms with the treatment response and short-term outcomes in patients with severe COVID-19. Methods: Our pilot study ...

Department of Orthopedic Surgery, the Affiliated Lihuili Hospital of Ningbo University, Ningbo 315040, China ...

Glucocorticoids can moderate this inflammatory effect due to receptor binding (NRC31-the gene encoded), influencing the expression of effector genes and pro-inflammatory cytokines. Another important ...

Glucocorticoid steroids improved muscle performance through distinct, sex-specific molecular mechanisms in mice, according to a Northwestern Medicine study published in the Journal of Clinical ...

but they get there through different pathways," McNally said. The findings suggest that weekly glucocorticoid steroid treatment is beneficial for improving muscle health and performance and is ...

Since their discovery, their adverse effects have counterbalanced their beneficial anti-inflammatory effects. Glucocorticoids exert their effects through both genomic and non-genomic pathways.