Researchers have identified a molecular pathway responsible for the spread of glioblastoma to surrounding tissue in the brain, as well as an existing drug that curbed tumor growth in animal models.

New pathway for potential glioblastoma treatment. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 08 / 190821163812.htm. Texas A&M University.

To discover the pathway cancer cells use to infiltrate the brain, researchers used large-scale gene editing technology to compare gene dependencies in glioblastoma when it was initially diagnosed ...

Their analyses identified the PTP4A2-ROBO1 pathway which is involved in axonal guidance—a signalling axis that helps establish normal brain architecture —that can become overrun by cancer cells.

Glioblastoma has been deadly and hard to treat, but researchers say they’ve made progress with bivalent CAR T-cell therapy delivered directly into the brain.

A new pathway that is used by cancer cells to infiltrate the brain has been ... published in Nature Medicine on Aug. 2, 2024, offers new hope and potential treatments for glioblastoma, ...

“In glioblastoma, we believe that the tumor hijacks this signalling pathway and uses it to invade and infiltrate the brain,” says co-senior author Sheila Singh, professor with McMaster’s Department of ...

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of ...

Probing further, Dr. Chen's team discovered that the epigenetic factor determining whether or not glioblastoma cells can proliferate indefinitely as cancer stem cells is their relative abundance ...