a,b, Immunohistochemical staining of mouse GBM induced by Ras and Akt stained with antibody to Gfap and nestin, respectively. c,d, Immunohistochemical staining with antibodies to K-Ras and virally ...

The genetic makeup and structure of glioblastoma tumors can shift dramatically across different regions of a single tumor, according to a Northwestern Medicine study published in Science Advances.

This study investigates the localization and clinical relevance of MFGE8 in GBM. Methods: We identified 11 adult patients at our center who had both an initial diagnosis and a relapse biopsy of GBM.

The study was published as a paper in Nature Medicine, titled “ Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a Phase I trial,” and ...

Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity. Cell Death & Disease , 2025; 16 (1) DOI: 10.1038/s41419-025-07514-2 Cite This Page : ...

动物模型突破. GFAP-cre;Nf1 loxP/+;Trp53-/+ 基因工程小鼠模型显示，围产期感染鼠巨细胞病毒(MCMV)可显著加速肿瘤发生。更突破性的进展是CEGBCs模型——将HCMV感染的人星形胶质细胞移植至小鼠脑内后，成功再现GBM的病理特征。

Patients with newly diagnosed glioblastoma who receive STUPP, which became standard of care in 2005, have a 2-year OS of 26.5% and 5-year OS of 9.8%, according to study background.

The one responder -- out of 18 patients with a diagnosis of GBM and EGFR amplification who had CAR T-cells injected into the cerebral ventricles to reach the cerebrospinal fluid (CSF) -- had a ...

Background: Glioblastoma (GBM) is an aggressive malignancy with median survival of approximately 2 years from initial diagnosis and 9 months after first progression. Effective treatments in the ...

Their findings were published in the current issue of Science Signaling. (Link is external) Glioblastoma is an incurable cancer with an average survival time after diagnosis of around 12-18 months, ...

CHICAGO — New data on two studies are bolstering hopes that CAR-T therapy, which uses engineered immune T cells to fight cancer, may be able to overcome one of the most difficult to treat ...