“and we hope to combine our data with the Korean Animal Model Archive to help build a national genetic variation dataset.” In 2013, the KMPC joined the International Mouse Phenotyping ...

The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale ...

1.2.3 The mouse as a model prior to the recombinant DNA revolution With the demonstration in the mouse of genetic factors that impact upon cancer, millions upon millions of animals were used to ...

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the ... regardless of the genetic mutation causing their disease.

Researchers at Karolinska Institutet have uncovered new insights into the mechanisms underlying autism spectrum disorder (ASD ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

More information: Meirui An et al, In vivo base editing extends lifespan of a humanized mouse model of prion disease, Nature Medicine (2025). DOI: 10.1038/s41591-024-03466-w . www.nature.com ...

trans-activating CRISPR RNA (crRNA:tracrRNA) and Cas9 protein and then to full-length synthetic sgRNA ribonucleoprotein (RNP) complexes. Applications of sgRNA in animal model generation and cell line ...

While the primary factors are genetic and can be linked to a family ... humans at risk of prostate cancer and a ...

Scientists say identification of two epigenetically different states in mouse model opens door to "entirely new world of ...