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生物通
25 天
树舌灵芝中高氧化羊毛脂烷三萜的发现及其通过TGF-β/Smad通路抑制肝 ...
本研究针对临床缺乏有效抗肝纤维化药物的现状,对树舌灵芝(Ganoderma applanatum)乙酸乙酯提取物进行系统研究,分离鉴定出11个羊毛脂烷三萜(含10个新化合物),其中applanoids J/K首次揭示具有B-seco-1,4-环己二酮新骨架。通过TGF-β1诱导的肝纤维化模型证实化合物2/4/6 ...
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