G 蛋白偶联受体（GPCRs）是药物研发的重要靶点，但信号转导复杂阻碍了药物开发。研究人员探索了 GPCRs 的偏向性信号传导和细胞内调节剂，发现其在精准医学中具有潜在应用价值，有助于开发更安全有效的药物。 在生命科学和医学领域，药物研发一直是攻克 ...

Nabla Bio's latest AI model update generates de novo antibodies for GPCRs with therapeutic-grade properties within a few ...

Debates over AI antibody design terminology have clouded the industry’s shared mission of bringing better therapeutics to the ...

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为解决G蛋白偶联受体(GPCR)中孤儿受体配体鉴定难题，研究人员开发了GzESTY检测技术。该研究通过优化GsGz嵌合体与cAMP生物传感 ...

Using a method similar to the earth satellite GPS, they could track the motions of a GPCR and observe it in action. Their findings, recently published in Science , provide guidance for designing ...

GLP-1R is a validated target in type 2 diabetes and probably the best-characterized class B1 GPCR from a structural perspective. GLP-1R is the only class B1 receptor with structurally characterized ...

A novel GPS NMR method enabled precise tracking of motions within the β 1-adrenergic GPCR, revealing that the receptor exists in a dynamic equilibrium among inactive, preactive, and active states.

o GPCR-associated signaling pathways in chondrocytes ... who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, ...

This study describes an improved adaptive sampling approach, multiple-walker Supervised Molecular Dynamics (mwSuMD), and its application to G protein-coupled receptors (GPCRs), which are the most ...