The mu opioid receptor (MOR) is a G protein-coupled receptor (GPCR) and is responsible for the effects of all medically used ... A recent development in opioid pharmacology has been the discovery of ...

Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala SE- 751 24, Sweden Department of Synthesis and Chemical Technology of Pharmaceutical Substances with ...

Septerna's GPCR platform shows promise, but execution risks, funding needs, and competition suggest caution. Click here to ...

疼痛是人们就医的首要原因，仅背痛一项就影响着全球超过 6 亿人。尽管存在使人成瘾的风险，阿片类药物在美国仍被广泛用于术后和严重疼痛的治疗。鉴于阿片类药物使用障碍造成的巨大经济负担和社会影响，美国联邦医疗保健机构已将开发更安全的替代品列为优先事项。

SOUTH SAN FFRANCISCO, CA, USA and BAGSVAERD, Denmark I May 14, 2025 I Septerna, Inc. (Nasdaq: SEPN) and Novo Nordisk today announced an exclusive global ...

GPCR?arrestin 复合物动态特性使 arrestin 识别机制不明。研究发现 arrestin2 与 β1肾上腺素能受体（β1AR）结合与配体及受体构象无关，由非受体连接的磷酸肽诱导 arrestin 构象变化驱动，静电作用为辅。揭示 arrestin 激活机制及 GPCR 识别多样性，助力偏向性信号研究与 ...

Announced Global Collaboration with Novo Nordisk to Develop Oral Small Molecules for Metabolic Diseases with Over $2.2 Billion in Potential Milestone Payments On Track to Select a Next-Generation Oral ...

SEP-631 is a selective oral small molecule MRGPRX2 negative allosteric modulator (NAM) in development for the treatment of mast cell diseases ... is a biotechnology company pioneering a new era of ...

Using a method similar to the earth satellite GPS, they could track the motions of a GPCR and observe it in action. Their findings, recently published in Science , provide guidance for designing ...