研究结论与讨论 本研究表明，Ib 型 MET 抑制剂通过 U 形结合模式与 MET 紧密结合，其中 vebreltinib 更易形成 U 形构象，有利于抑制激酶活性。在 BBB 通透性方面，vebreltinib 和 capmatinib 表现出较低的能量屏障，更易穿透 BBB，且 vebreltinib、savolitinib 和 glumetinib 与 P-gp 的 ...

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