These effects of DOX were partially alleviated by rAAV9 expressing shRNA-ATG5 and deteriorated by rAAV9-ATG5. We demonstrated that genetic ATG5 knockdown or autophagy inhibition by chemical inhibitors ...

Smooth muscle cells with the Tgfbr1 mutation seem to be unable to properly degrade excess Gata4 protein, resulting in its accumulation, MacFarlane says. While Gata4 is necessary for many processes ...

Results We found a novel mutation in a highly conserved residue in the T-box DNA binding domain (I121M ... a more dynamic structure of the protein. Moreover, Tbx20-I121M resulted in a significantly ...