Scientists have discovered a biochemical switch that seals a cell’s fate. A buildup of the protein GATA4 forces cells to enter a permanently static state known as senescence, researchers report ...

300 ng Gata4 mE360del or 300 ng TBX5. Immunoblots were used to verify appropriate protein expression. mG295S was consistently expressed at lower levels than wild type, necessitating ...

The team pinpointed a mutation in the gene Gata4, which codes for a protein of the same name, as the cause of the birth defects, according to a statement. Fast forward 7 years: multiple family ...

Smooth muscle cells with the Tgfbr1 mutation seem to be unable to properly degrade excess Gata4 protein, resulting in its accumulation, MacFarlane says. While Gata4 is necessary for many processes ...

Smooth muscle cells with the Tgfbr1 mutation seem to be unable to properly degrade excess Gata4 protein, resulting in its accumulation, MacFarlane says. While Gata4 is necessary for many processes ...

In this image of cells in the aorta, the red dots represent cells expressing the protein Gata4, which can be harmful when it accumulates. Studying the cells of people and genetically engineered ...