For the past five years, researchers at Leipzig University have been working on fundamentally new methods for selectively ...

February 1, 2012 (Vol. 32, No. 3). Tocopherol Modification Improves Product Purification and Aids Delivery into Cells. The use of oligonucleotides as therapeutic agents is of great interest ...

Their efforts culminated in a new approach: enzymatic DNA synthesis. 4 Although the method is still in its infancy, investors are flocking to a growing list of biotechnology companies, lured by the ...

The scientists at Leipzig University, together with their collaborators at Purdue University (US), have published a summary ...

A method for synthesizing DNA from 40-mer oligonucleotides, which we used to generate a 32-kb DNA fragment, is explained. DNA sequences are synthesized as ∼500 bp fragments (synthons) in a two ...

F rom synthetic biology and gene therapy to data storage and biofuel production, the demand for synthetic DNA is rising.. Chemical synthesis. Phosphoramidite oligonucleotide synthesis is the ...

Ansa’s proprietary enzymatic oligonucleotide synthesis technology is based on its patented Polymerase-nucleotide Conjugate reagents that can rapidly extend a DNA molecule by one base at a time.

Both methods produced a common precursor that converts into a conjugation-ready building block that is primed for application in ADP-ribose synthesis, according to Tanaka.

One method of achieving this is the use of a cleavable disulphide bridge between the delivery agent and the oligonucleotide. However, when used in vivo there is the potential for toxic effects ...