Nature Methods - Using 600 oligonucleotides with 60 bases each and three enzymes, the authors assemble the entire mouse mitochondrial genome in four isothermal reactions. Skip to main content ...

February 1, 2012 (Vol. 32, No. 3). Tocopherol Modification Improves Product Purification and Aids Delivery into Cells. The use of oligonucleotides as therapeutic agents is of great interest ...

One method of achieving this is the use of a cleavable disulphide bridge between the delivery agent and the oligonucleotide. However, when used in vivo there is the potential for toxic effects ...

“The data presented today by Codexis are truly unprecedented—I believe this is the first enzymatic synthesis of a full-length oligonucleotide from starting material through the attachment of a ...