1 Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Modena, Italy 2 Department of Internal Medicine, Unit of Clinical and Molecular Hepatology, University ...

6 Institute of Systems, Molecular and Integrative Biology, University of Liverpool and Department of Gastroenterology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK Iron ...

Instead, the condition showed greater resemblance to another hereditary haemochromatosis variant, type 4, which had recently been described in the literature and named ferroportin disease (5). Normal ...

Rusfertide, a synthetic hepcidin mimetic, acts similarly by binding to the ferroportin protein on cell membranes, promoting its internalization and degradation. This reduces iron efflux from cells and ...

铁代谢紊乱：DOX上调转铁蛋白受体（TfR1）并抑制铁转运蛋白（ferroportin），导致细胞内游离铁蓄积，加速Fenton反应。 动物实验显示，给予锌氧化物纳米颗粒可通过恢复GPX4活性，显著减少DOX诱导的睾丸萎缩和精子数量下降。 非铁死亡机制：传统通路的协同破坏 HPG ...

铁代谢的双向免疫调控 巨噬细胞通过膜受体（如TfR1）和铁转运蛋白（Ferroportin）精密调节胞内铁浓度。低铁环境会激活缺氧诱导因子（HIF-1α），促进促炎性细胞因子分泌；而高铁状态则通过铁死亡（Ferroptosis）途径削弱中性粒细胞的杀菌能力。在适应性免疫中 ...

Rusfertide: A Novel Approach to Iron Regulation Hepcidin is the master regulator of systemic iron homeostasis. It controls iron through ferroportin, a transmembrane protein responsible for delivering ...

Rusfertide is an investigational hepcidin mimetic peptide therapeutic. It binds to ferroportin, and downstream blockade results in reduced iron availability in the bone marrow, helping to prevent ...

During atherosclerosis, lipid-rich plaques are formed in large- and medium-sized arteries, which can reduce blood flow to tissues. This situation becomes particularly precarious when a plaque develops ...

Metabolic hyperferritinemia (MHF) is associated with the occurrence and progression of cardiovascular disease. Our aim is to investigate the prevalence of MHF, as defined by the latest consensus, and ...

Rune Johan Ulvik (born 1947) is a specialist in clinical chemistry, professor and senior consultant. The author has completed the ICMJE form and declares no conflicts of interest. Hereditary ...