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为解决 PI3K 抑制剂临床疗效受耐药机制限制的问题，研究人员合成一系列二茂铁修饰的 PI3K 抑制剂。体外实验显示化合物 3d 对乳腺癌 4T1 细胞和结肠癌 CT26 细胞有优异抗增殖活性，体内实验也证明其有良好抗肿瘤活性，为抗癌治疗提供新方向。 恶性肿瘤，这个 ...