In many ways, that relationship revolves around a specific protein called the farnesoid X receptor, or FXR, which helps maintain a healthy gut through its intimate relationship with bile acids.

The Swiss pharma said it is to begin a phase IIb trial of one of its Farnesoid X receptor (FXR) agonists in combination with Allergan’s cenicriviroc in NASH. A group of around half a dozen ...

At the moment, Intercept’s only other clinical-stage candidate is INT-787, a farnesoid X receptor agonist in a phase 2 study involving patients with severe alcohol-associated hepatitis (sAH).

A study demonstrated that pharmacological activation of the farnesoid X receptor (FXR) in a mouse model could prevent PNAC by restoring liver function and reducing inflammation. This suggests that ...

In many ways, that relationship revolves around a specific protein called the farnesoid X receptor, or FXR, which helps maintain a healthy gut through its intimate relationship with bile acids. FXR ...

Our lab identified that excessive copper concentrations decreased metabolic nuclear receptor activity (FXR - farnesoid X receptor, HNF4a – hepatocyte nuclear factor, and LRH-1 – liver receptor homolog ...