Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling ...

Please provide your email address to receive an email when new articles are posted on . FXR314-treated patients achieved up to 22.8% reduction in liver fat content at 16 weeks vs. 6.1% with ...

Organovo. has filed a patent for compounds that act as farnesoid X receptor agonists. The patent includes methods of making these compounds, pharmaceutical compositions, and their use in treating ...

In a recent study published in Nature, researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Farnesoid-X receptor (FXR), as a nuclear receptor activated by bile acids, is a vital molecule involved in bile acid metabolism. Due to its expression in immune cells, FXR has a significant effect on ...

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, and was identified as a receptor of bile acids (BAs) (Li C. et al., 2019). There is one human gene for FXR (NR1H4) ...

TERN-101 is a potent, non-bile acid farnesoid X receptor (FXR) agonist. FXR activation has been shown to prevent the progression from histological liver fibrosis to NASH.

Major finding: Farnesoid X receptor is a tumor suppressor linking intestinal self-renewal and bile acid homeostasis. Mechanism: Bile acids antagonize FXR function to drive transformation of intestinal ...

Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, is a transcription factor activated by endogenous bile acids. In addition to the liver and small intestine where FXR plays an ...

As a ligand-activated transcription factor, farnesoid X receptor (FXR) is abundantly expressed in the liver and small intestine, where it plays an important role in the maintenance of bile acid, lipid ...