Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling ...

Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ...

Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, ...

Moreover, there is a physiologically functional cross-coupling between ERα and liver X receptor alpha (LXRα) which is another important regulator of hepatic lipid metabolism . Estrogen is negatively ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

Treatment with norBNI normalizes sex-specific behavioral phenotypes of male and female DAT Val559 mice. Credit: Molecular Psychiatry (2025). DOI: 10.1038/s41380-025-03055-4 ...

Understanding the patterns of acquired resistance to epidermal growth factor receptor (EGFR) TKI treatment has led to more effective combination therapy and continues to drive development of novel ...

Associate Professor Sebastian Furness from the UQ School of Biomedical Sciences said the team discovered the body's receptor for ghrelin had a critical role in the normal function of the spinal ...

The object, known as ASKAP J1832-0911, emits pulses of radio waves and X-rays for two minutes every 44 minutes. The paper, "Detection of X-ray Emission from a Bright Long-Period Radio Transient ...

Here, we show that, in the murine small intestine, the IL-18 receptor is expressed by rare IECs that we identified to be a subset of enterochromaffin cells (ECC). While these cells are the major ...