Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling ...

Here the authors show that the transcriptional coactivator YAP exerts a repressor role on Farnesoid X receptor (Fxr), the master transcriptional regulator of BA synthesis, contributing to the ...

Find more information on the Altmetric Attention Score and how the score is calculated. Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the ...

引言在我们的身体里，肝脏是一个重要的“化工厂”，默默执行着上百种关键任务。然而，现代生活方式正让这个勤劳的器官不堪重负。脂肪肝，正以前所未有的速度席卷全球。当脂肪在肝脏中过度堆积，并引发炎症和损伤时，它就演变成一种更具威胁性的疾病——代谢功能障碍相关 ...

Elon Musk's X is launching XChat in beta with encryption, vanishing messages, and file sharing. XChat aims to enhance privacy on X, aligning with Musk's vision for an everything app. XChat's ...

Forbes contributors publish independent expert analyses and insights. I write about how bitcoin, crypto and blockchain can change the world.

Associate Professor Sebastian Furness from the UQ School of Biomedical Sciences said the team discovered the body's receptor for ghrelin had a critical role in the normal function of the spinal ...

An international team reported Wednesday that this celestial object — perhaps a star, pair of stars or something else entirely — is emitting X-rays around the same time it's shooting out radio ...

In this phase 3, open-label, randomized trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer who had received one ...

The "key?" A molecule that targets a specific protein called the kappa opioid receptor (KOR). Opioids are commonly known as powerful painkillers with strong psychoactive effects. They increase ...

After revealing the news of the remix just last week, the respective estates of XXXTentacion and Juice WRLD have revealed the musicians’ dual-minded edition of X’s “whoa (mind in awe).” ...