为探究 mtDNA 突变在 ALS - FTLD 发病机制中的作用，研究人员用 hiPSCs - 衍生脑类器官研究，发现 C9ORF72 突变星形胶质细胞 mtSNV 负担高，或助力靶向治疗。

Background Frontotemporal lobar degeneration (FTLD) is a rare, heterogeneous form of dementia that can affect younger people, in which neuropsychiatric symptoms (NPS) are common. The Integrated ...

New research warns that blood tests for Alzheimer’s disease may be unreliable, particularly for Black patients. A recent ...

衰老过程伴随着基因突变和表观遗传变化的累积，这些变化逐渐破坏分子和细胞水平的功能稳态，导致蛋白质稳态丧失和线粒体功能异常。在神经退行性疾病背景下，蛋白质稳态的丧失极大地促成了包括 β-淀粉样蛋白（Aβ）、过度磷酸化的 tau ...

TDP-43 pathology is evident in both the hippocampus and the extra-hippocampal regions with low levels of AD pathological changes (Braak NFT stages≤IV) and absence of clinical features of FTLD.80 81 (1 ...

They sought to examine both clinical importance and detectability of AD in FTLD-related neurodegenerative syndromes via three standard plasma biomarkers, phosphorylated tau 217 (p-tau217 ...

Methods In total CSF and serum of 294 patients were analysed. The diagnostic groups comprised: ALS (n=75), frontotemporal lobar degeneration (FTLD) (n=33), Alzheimer’s disease (n=20), Parkinson’s ...

AL002 misses Phase 2 goal in early Alzheimer's. Key Phase 3 data for latozinemab in 2025. Click here to read why ALEC is a ...