The incidence of Human Papillomavirus (HPV)–associated oropharyngeal cancers—tumors of the back of the mouth and throat—is ...

The researchers analyzed changes to gene expression in ecDNA formed by HPV and human DNA hybridization in oropharyngeal tumor ...

Extrachromosomal DNAs (ecDNAs) encode oncogenic driver proteins, regulatory elements, immunomodulators, and genes of yet-unknown oncogenicity (Panel A). They exist as circular pieces of DNA in the ...

Focal amplifications in the cancer genome, particularly extrachromosomal DNA (ecDNA) amplifications, are a pivotal event in cancer progression across diverse cancer contexts. These megabase-scale ...

The American doctor has revealed that enigmatic DNA circles are present in more than half of patients with highly aggressive ...

Stanford University, Palo Alto, CA.

The incidence of Human Papillomavirus (HPV)-associated oropharyngeal cancers — tumors of the back of the mouth and throat — is rising. If caught early, most of these cancers have a high ...

此研究通过对尿路上皮癌中ecDNA的系统解析，揭示了其在驱动多灶性肿瘤演进和异质性形成中的关键作用，并证实了其在肿瘤发生早期即参与调控。该项成果在染色体外环状DNA（ecDNA）研究领域取得了突破性进展，随即引起了国内外媒体的高度关注。研究论文不仅在 ...