Our results highlight enolase as metabolic regulator of severely exhausted T cells ... These exhausted T cells lack sufficient antiviral function but the mechanisms behind this dysfunction are unclear ...

† New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 500-712, Republic of Korea ‡ College of Pharmacy, Sunchon National ...

The defects in molecular and cellular processes that constitute the triggers of specific pathologies are referred to as mechanisms of disease. Research in this area is vital for designing ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

Mechanism has teased its first Switch 2 accessory coming this summer. The company, which made its name with the Deckmate accessory ecosystem for Steam Deck and other handhelds, has unveiled the ...

Understanding the mechanisms that coordinate this collective behavior remains a significant challenge in biology and the physics of living systems, but a better understanding could have ...

The latest version of the 'Crocodilus' Android malware has introduced a new mechanism that adds a fake contact to an infected device's contact list to deceive victims when they receive calls from ...

We are reaching alarming levels of AI insubordination. Flagrantly defying orders, OpenAI's latest o3 model sabotaged a shutdown mechanism to ensure that it would stay online. That's even after ...

The Council adopted today its negotiating position (general approach) on one of the proposals of the so-called ‘Omnibus I’ legislative package, which simplifies and strengthens the EU’s carbon border ...

For context, OpenAI's Codex Mini, o3, and o4-mini models managed to bypass the shutdown commands and mechanisms. Codex sabotaged the mechanism 12 times, while o3 bypassed the shutdown command 7 times.

A research team at the University of Barcelona's Institute of Neurosciences (UBneuro) has discovered new molecular mechanisms related to the cognitive decline associated with Alzheimer's disease ...