Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome ...

An Escherchia coli K12 strain carrying the HhaII methylase and restriction genes on two separate compatible plasmids, pSK5 and pSK7, is used to overproduce the restriction endonuclease. Plasmid pSK5 ...

Effects of setup margin and biology tracking zone variations on dosimetric plan quality and treatment feasibility in biology-guided radiotherapy for bone metastasis.

Traws Pharma, Inc. (NASDAQ: TRAW) ("Traws Pharma”, "Traws” or "the Company”), a clinical-stage biopharmaceutical company ...

In this study, we show that Metnase possesses a unique endonuclease activity that preferentially acts on ssDNA and ssDNA-overhang of a partial duplex DNA. Cell extracts lacking Metnase poorly ...

Enhanced DNA alkylation and weakened DNA repair capacity in cancer cells are responsible for the effectiveness of DNA-alkylating therapies. 5′-Flap endonuclease 1 (Fen1) is an important enzyme ...

ABSTRACT: Gene editing technology, which allows for precise modifications to an organism’s genome, has emerged as a transformative tool in genetic engineering. This review introduces the fundamental ...

Epigenetic changes do not alter the genetic code itself, but by changing how DNA is organized within the cell, epigenetic ...

ABSTRACT: Gene editing technology, which allows for precise modifications to an organism’s genome, has emerged as a transformative tool in genetic engineering. This review introduces the fundamental ...

Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the double strand break can result in insertion or deletion mutations, while repair pathways can be ...