In the endogenous pathway, MHC class I molecules present endogenous antigens derived from pathogen-specific proteins produced within infected cells. However, in the exogenous pathway, MHC class II ...

Certain peptides are preferentially loaded onto MHC I, further processed for immune surveillance (antigen processing) and presented on the cell surface. Peptides that come from normal endogenous ...

Figure 1: The Nur77–GFP BAC transgenic reporter is responsive to antigen-receptor signalling in vitro. The reporter responded to TCR-dependent signalling in vivo, as shown by GFP expression at ...

The elaboration of an efficient immune response against pathogens involves complex intracellular antigen-processing events. Endogenous antigens such as viral proteins synthesized by infected host ...

These antigens are typically recognized by the immune system as non-self and trigger an immune response to eliminate the invading organism. Endogenous antigens are substances that originate within the ...

Antigen escape is an even more significant ... bystander immunity in the form of epitope spread with activation of endogenous T cells directed against whatever neoepitopes exist in an individual ...

Certain peptides are preferentially loaded onto MHC I, further processed for immune surveillance (antigen processing) and presented on the cell surface. Peptides that come from normal endogenous ...

SQZ AACs are a novel cellular immunotherapy candidate designed to transport tumor-specific antigen and TLR agonists to the patient’s endogenous, professional, antigen presenting cells in vivo.

At enrollment, 50% of participants were seropositive for endogenous neutralizing antibodies and 59% had anti-nucleocapsid antibodies. Also, 95% of participants had plasma antigen levels of 3 ng/L ...