We report the identification of the muniscin family of endocytic adaptors that is conserved from yeast to human beings. Solving the structures of yeast muniscin domains confirmed the unique ...

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Lysosomes are dynamic organelles that receive membrane traffic input from the secretory, endocytic, autophagic and phagocytic pathways. They can also fuse with the plasma membrane. Live-cell ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Ovarian cancer remains the leading cause of death among cancers affecting the female reproductive system, largely because current treatments are not effective once the cancer has spread (metastasized) ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

This review describes the present knowledge on the organization of the most important structures and organelles found in the protozoan, such as the cell surface, flagellum, cytoskeleton, ...

a group of membrane-bound proteins that mediate vesicle fusion in endocytic and secretory pathways, was required for the 6-OHDA-induced extracellular secretion of PARK7. The researchers also ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, ...

The Flower protein was suggested to couple the fusion of synaptic vesicles (SVs) to their recycling in different model organisms. It is supposed to trigger activity-dependent bulk endocytosis by ...

3,4 Functionally, pattern-recognition receptors can be divided into three classes: secreted, endocytic, and signaling. Secreted pattern-recognition molecules function as opsonins by binding to ...