Previous studies have identified a CAM termed E-selectin as a promising target. Its inhibition can potentially reduce the metastatic burden in lung and colon cancers with minimal side effects.

GlobalData’s report assesses the drugs in the E Selectin pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline. Buy the report here.

Although Tie2, sRAGE, and E-selectin also fell more in the usual care than the CPAP group, these differences were not statistically significant. Greater 12-month levels of Ang-2 and sRAGE, a marker of ...

According to Jonas, e-selectin is not yet among the biomarkers that aid decision-making in AML. Those biomarkers include genetic lesions, mutations, and chromosome abnormalities. Approved therapies ...

BACKGROUND—Bleomycin (BLM), a well known anti-cancer drug, often causes acute lung injury and fibrosis by mechanisms that are not well understood. It is suspected that some proteases and active oxygen ...

Brian Jonas, MS. PhD, discusses e-selection as a biomarker in acute myeloid leukemia, and how e-selectin inhibition works along with chemotherapy to decrease tumor growth. Brian Jonas, MD, PhD, ...

“E-selectin is normally expressed on endothelial cells and is upregulated in response to inflammation, which includes IL-1, tumor necrosis factor, and lipopolysaccharide,” Uy explained. “When ...

E-Selectin-Overexpressing Mesenchymal Stem Cell Therapy Confers Improved Reperfusion, ... Representative PCR gel electrophoresis of mice lung and liver tissue demonstrating lack of GFP expression ...

Results of immunohistochemical studies show different levels of expression of these molecules that reflect their unique structural and functional characteristics. 23–28 Circulating forms of VCAM-1, ...

Systemic psoriasis treatment is correlated with E-selectin and vascular cell adhesion molecule 1 (VCAM-1) plasma concentrations and may be associated with the risk for cardiovascular disease, ...