Cytokinetics' hopes of resurrecting cardiac myosin activator omecamtiv mecarbil have suffered another setback, after the drug failed to show a benefit in a phase 3 heart failure study. In the ...

http://orcid.org/0000-0003-1053-7840Paul M Haydock, http://orcid.org/0000-0002-8126-9583Andrew S Flett To review the pathophysiology of heart failure with reduced ...

Heart failure causes vary, but the result is a weakened heart that's limited in its capacity to meet your body's need for oxygen and nutrients delivered in the blood supply. This is due to loss of ...

The role of ACE inhibitors in the management of HFPEF is less significant compared with their role in the management of heart failure with ... their study drug treatment, which reduces the ...

Moderna is already riding high on the strength of its mRNA-based COVID-19 vaccine, but the broader potential of its technology has been shown in a new AstraZeneca-partnered candidate for heart ...

Professor Allan Struthers, Department of Clinical Pharmacology & Therapeutics, Ninewells Hospital, Dundee DD1 9SY, UK email: a.d.struthers{at}dundee.ac.uk If you wish ...

In general, rhythm control is more effective at reducing symptoms, improving quality of life, and preventing progression of atrial fibrillation and development of related complications like heart ...

Experimental pharmacology is the basis of drug discovery. The discovery of novel drugs can be done through the identification ... Nefopam, a centrally acting analgesic with anticholinergic properties, ...

Methods: Utilizing summary statistics from extensive genome-wide association studies (GWAS), we investigated the interplay among the gut microbiome, 1,400 plasma metabolites and heart failure. We ...

Atrial fibrillation (AF) and chronic heart failure (CHF) are two major and even growing cardiovascular conditions that often coexist. However, few data are available to guide treatment of AF in ...

Cognitive decline comes sooner for people with heart failure Management of heart failure is complex and requires strict adherence to instructions, medications and care coordination Date: April 3 ...