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人腺病毒五邻体-十二面体纳米颗粒在小鼠模型中诱导增强型中和抗体 ...
本研究针对人腺病毒7型(Ad7)引发的严重肺炎缺乏有效疫苗的现状,创新性利用昆虫细胞-杆状病毒表达系统(IC-BEVS)构建了含五邻体基底(penton base)和纤维(fiber)的十二面体纳米颗粒(Pt-Dd)。实验证实Ad7 Pt-Dd能高效诱导中和抗体和细胞免疫反应,在转基因 ...
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