In normal cells this Wnt signaling pathway is carefully controlled by a gene called APC, which functions to prevent excessive cell growth and tumor formation. However, the majority of colon cancers ...

we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer. Cell signaling plays a pivotal role in a variety of cellular processes in response ...

tissue organization and cell polarity. 11,12 In this review, we describe the recent evidence that disrupting the apical–basal polarity machinery rewires signaling pathways that couple ...

For many years, the Ras signaling pathway has triggered both hope and frustration in the field of cancer research. In normal health, Ras signaling is central to the regulation of intracellular ...

This is certainly the case for the excessive cell growth ... that a well-known signaling pathway helps cancers grow by blocking the pro-growth signals from a second major cancer pathway.

Overactivity of this signaling pathway in mature cells is thought to be a major driver in the development of cancer. "Our research points to a new regulatory role for cholesterol, and also ...

As multiple lines of evidence reveal, signaling pathways originally ... section of the laboratory of cell and developmental signaling at the National Cancer Institute. Investigators in Dr.

Many of these alterations are often associated with signaling pathways which regulate cell growth and division, cell death, survival, invasion and metastasis, and angiogenesis. Almost all cancer ...

Their model shows a direct connection between gene regulation and metabolic pathways and how cancer cells take advantage of ... molecules that are important to signaling but at high levels can ...

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study suggests. Cancer cells ...

LMU researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells. Colorectal cancer is one of the most common types of cancer worldwide.

"This establishes a new paradigm in the field that the overactivation of a pathway involved in oncogenic signaling is detrimental to cancer cells. This discovery sheds light on how interferon ...