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新年开新局!温医大在国际顶刊Nature Review Drug Discovery发表综述
成纤维细胞生长因子(FGF)在人类发育、代谢和组织稳态中发挥重要的调控作用。一直以来,FGF被认为仅在促进伤口愈合方面有应用前景。近年来,对于FGF的代谢调控功能的系统阐明为FGF类相关代谢性疾病治疗药物的研发提供了重要理论依据,以FGF19和FGF21为代表的蛋白改构体更是分别有望获批用于治疗原发性硬化性胆管炎和代谢综合征相关性脂肪性肝炎(MASH)。因此,FGF在代谢性疾病中的应用前景已经成为 ...
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