Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA ...

1UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA.

Mouse whole-lung RNA was prepared using TRIzol (Invitrogen, Carlsbad, CA). Flow sorted cells RNA was extracted using the RNeasy Plus Micro Kit (Qiagen, Germantown, MD). Gene mRNA expression (Flt3, ...

There have been reports of sympathetic and parasympathetic fibers innervating dendritic cells (DCs) in the spleen (22 ... with increased expression of FLT3L and larger fractions of CD11c+ cells ...

FLT3L (Fms-like tyrosine kinase 3 ligand) is an endogenous factor that stimulates the differentiation of migratory and lymph node-resident classical DCs. 20 While these animals are healthy at baseline ...

Rationale Dendritic cells (DC) accumulate in the lungs of patients with idiopathic lung fibrosis, but their pathogenetic relevance is poorly defined. Objectives To assess the role of the FMS-like ...

Conventional dendritic cells (cDCs), cDC1s and cDC2s, are hematopoietic cells that play central roles in mounting T cell responses. It is important for host protection that cDCs are continuously ...