Tumor antigens are captured and displayed by antigen processing and presentation machinery (APM) on the cell surface by HLA-I, making it possible for CD8 + T cells to eliminate cancer cells.

a gene and cell therapy firm, for the tumor antigen-specific antibody sequence. The agreement grants GC Cell exclusive rights to utilize DAAN Biotherapeutics' antibody sequence in the research and ...

(3) Genetic modification of the T cells is performed by inserting the CAR gene, enabling them to recognize tumor-specific antigens. (4) CAR-T cells are expanded ex vivo to achieve sufficient ...

Therefore, we investigated the relationship between hypoxia and antigen presentation using colorectal cancer cell lines. We found that hypoxia leads to a reduction in MHC I expression and subsequently ...

Transformation of antigens derived from pathogens or tumor cells into MHC class I and II binding peptides is essential for ... Greater knowledge about the molecular mechanisms underlying antigen ...

The following is a summary of “Mitochondrial control of antigen presentation in cancer cells,” published in the November 2023 issue of Oncology by Soler-Agesta et al. If cytotoxic T lymphocytes come ...

Failed T cell ... presentations pathways may be overcome by NK cell-based immunotherapy. This approach may still be limited by the presence of immunosuppressive myeloid populations. Here, we ...

Several steps are involved in this process, including: 1) peptide generation and trimming in the proteasome; 2) peptide transport; 3) assembly of the MHC class loading complex in the endoplasmic ...