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其中4例符合染色体碎裂标准，断裂点分析提示非同源末端连接(NHEJ)是主要修复机制。通过FISH和Decoil算法排除了染色体外DNA(ecDNA)的可能性，确认扩增为染色体内事件。 DYRK1A被鉴定为关键效应分子 单细胞多组学分析显示，在2.7 Mb的最小扩增区(MAR)内，DYRK1A是唯一 ...

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