The chromosome features a 24-centiMorgan (cM) inversion between Trp53 (also known as p53) and Wnt3 on mouse chromosome 11 that is recessive lethal and dominantly marked with a K14-Agouti transgene2.

TFAP4 binds to the promoters of DVL1 and LEF1, further enhancing β-catenin stability and activating the expression of downstream genes such as CCND1, CD44, JUN, and TCF1. Additionally, this pathway ...

A new paper published in Nature on June 4 shines light on how an enigmatic part of male aging—the loss of Y chromosomes—is connected with a higher risk of dying from cancer.. In an analysis of ...

The loss of the Y chromosome in tumour cells is linked to poor outcomes for people with cancer 1, but this genetic alteration might also compromise immune cells that would otherwise fight the ...

When cancer cells in male patients and immune cells in their tumors both lose the Y chromosome, those patients tend to experience poorer outcomes than patients without Y chromosome loss, according ...

A leaked Dr Lal PathLabs report alleges Olympic gold medalist Imane Khelif possesses male chromosomes, reigniting the gender eligibility debate. The 2023 test, commissioned by the IBA, led to ...

Replication, segregation, gene expression, and inheritance are essential features of all eukaryotic chromosomes. To delineate the extent of conservation of chromosome functions between humans and ...

Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During mitosis, centromeres serve as assembly sites for complex protein ...

In a major leap forward for genetic and biomedical research, two scientists at the University of Missouri have developed a powerful new artificial intelligence tool that can predict the 3D shape of ...

In a major leap forward for genetic and biomedical research, scientists have developed a powerful new artificial intelligence tool that can predict the 3D shape of chromosomes inside individual ...

Get Instant Summarized Text (Gist) A new AI tool accurately predicts the 3D structure of chromosomes in individual cells, overcoming challenges of noisy and incomplete single-cell data.

Background: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) accounts for 20–30% of adult ALL cases and is characterized by high mortality and aggressive progression. Standard ...