A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can ...

Figure 1: DSBs are tightly linked to mutations over the Ramos immunoglobulin V H and V λ regions. We next wanted to determine whether the appearance of DSBs over mutating loci was dependent on ...