Disrupting the G-loop cycle causes transcriptome dysregulation and genome instability, revealing key role in cell survival and homeostasis.

In eukaryotic cells, the essential function of DNA replication is carried out by a network of enzymes and proteins, which work together to rapidly and accurately duplicate the genetic information of ...

This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data ...

Sequences that form DNA secondary structures, such as G‐quadruplexes (G4s) and intercalated‐Motifs (iMs), are abundant in the human genome and play various physiological roles. However, they can also ...

Recent findings reveal that early mouse embryos replicate their DNA in a unique, uniform manner, which changes after the embryo grows beyond four cells. This early-stage replication is slower and more ...

The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to keep parts of the replication machinery from ...

Okazaki fragment. dna replication stock illustrations DNA Replication diagram. DNA Polymerase enzyme syntheses.... The types of DNA mutation: Deletion, Substitution, Inversion, Insertion and ...

Given the success of this Research Topic, we would like to launch a second edition of the topic. DNA replication, a central event for cell proliferation, is the basis of biological inheritance.

DNA continually undergoes a process of replication and division and errors can sometimes occur in the process. It is essential for the biological system to have a mechanism in place to detect and ...

How skin cancer virus outcompetes DNA ... images, which are essentially just a snapshot in time,” said Moore. “The C-trap allows us to watch proteins bind to a single molecule of DNA in real ...