Since DNA ligation is essential for DNA replication and repair, DNA ligases have emerged as a promising target for cancer treatment. Its inhibitors block ligase activity, preventing cancer cells from ...

Binding cooperativity guides the formation of protein−nucleic acid complexes, in particular those that are highly regulated such as replication origins and transcription sites. Using the DNA binding ...

The USP50 protein plays a key role in regulating the balance between nuclease and helicase activity during essential cellular processes. A new study has identified a protein that plays a key role in ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication ... found that when USP50 is absent during replication activity, cells attempted to use various ...

Recent findings reveal that early mouse embryos replicate their DNA in a unique, uniform manner, which changes after the embryo grows beyond four cells. This early-stage replication is slower and more ...

Diagram of DNA replication. Process by which a double stranded... The graphic shows the duplication of a DNA chain on a gray background. Vector image The graphic shows the duplication process of a DNA ...

Given the success of this Research Topic, we would like to launch a second edition of the topic. DNA replication, a central event for cell proliferation, is the basis of biological inheritance.

Under conditions of replication stress, RIF1 protects nascent DNA at stalled replication forks from degradation by the DNA2 nuclease. How these RIF1 activities are regulated at the post-translational ...

several proteins that are essential for DNA replication. Cyclin E/CDK2 activity inhibits pre-replication complex (pre-RC) formation (red arrow) and stimulates pre-initiation complex (pre-IC) formation ...

DNA replication complexes are often prematurely ejected from sites of DNA replication. Left unrepaired, this situation results in incomplete genome replication and cell death. All cells have therefore ...