Survival is promoted through repair of these lesions by a number of DNA repair pathways. The efficacy of anticancer drugs is highly influenced by cellular DNA repair capacity. Inhibitors of DNA ...

However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back together through several different mechanisms, known as DNA repair pathways. Some cancers, however, can ...

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

image: DSB repair by SMARCAD1, MSH2, and EXO1. view more Credit: Institute for Basic Science. DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes.

The Role of DNA Repair Pathways in Antibody Somatic Hypermutation. 11h. In a recent online publication in SCIENCE CHINA Life Sciences, ... (BER) or mismatch repair (MMR) pathways, ...

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

“In one particular DNA repair pathway, it takes about 30 proteins to go from finding the pothole to putting in the repair patch. While we can’t observe all of these proteins at once, ...

Published online May 16 in the journal Cell, the report describes the molecular mechanism behind a DNA repair pathway that counters the mistaken inclusion of a certain type of molecular building ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

These are considered the most severe type of DNA damage, capable of causing genetic mutations or cell death. Cells maintain genome integrity by having various pathways to repair DSBs. Among the ...