Can we exploit the DNA repair pathways in cancer cells to increase the efficacy of existing and future cancer treatments? This Review discusses the current state of play. DNA repair pathways can ...

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

DNA damage response, or DDR for short, is the technical term for this. Specific signaling pathways usually initiate the immediate recognition and repair of DNA damage, thus ensuring the survival ...

The researchers were working on a DNA repair pathway, known as the Fanconi Anaemia [FA] pathway, which was identified more than twenty years ago. DNA is constantly damaged throughout our lives by ...

A study reveals significant genomic differences in metastatic prostate cancer among veterans, highlighting the need for ...

Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

“These pathways are important for preventing exacerbation of DNA ... greatly increasing the time cells have to repair DNA damage.” For years, Melendy and his colleagues have been studying two types of ...

A new hereditary condition has been discovered that affects patients' ability to repair DNA—leaving them both at greater risk ...

FDA approves updated labeling for Talzenna plus Xtandi in men with HRR gene-mutated metastatic prostate cancer, showing a ...

T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into effector cells that destroy pathogens.