The crystal structure of an archaeal 5' flap endonuclease suggests a common mode of action in this divergent group of essential replicative enzymes. Figure 1: The flap endonucleases (5' nucleases ...

The presence of the central DNA flap in HIV vectors enhances gene transduction in primary neural cells. To determine whether TRIP vectors, which include the central DNA flap, allow improved ...

They were hardly modest, these two brash young scientists who in 1953 declared to patrons of the Eagle Pub in Cambridge, England, that they had "found the secret of life." But James Watson and ...

In the late nineteenth century, a German biochemist found the nucleic acids, long-chain polymers of nucleotides, were made up of sugar, phosphoric acid, and several nitrogen-containing bases.