Such probes are sensitive, even to single base differences in target DNA. Freed from the constraint of needing hydrogen bonding to achieve rapid, high-fidelity DNA synthesis, one may be able to ...

(Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base pair, named after James Watson and Francis Crick, who first proposed the double helix structure of ...

Double-stranded DNA is composed of two ... sugar-phosphate backbones through interactions called hydrogen bonds. In cells, the DNA helix is often overwound, causing a phenomenon known as supercoiling.

One of the most important properties of guanine is its ability to form three hydrogen bonds with cytosine. This strong base pairing is crucial for the stability of the DNA double helix and the ...