首先，研究人员在体外使用IFNαA+CD40 Ab刺激BMDC模拟体内DC与CD4+T细胞之间的刺激信号，RNA-seq揭示一部分基因在IFNαA+CD40 Ab刺激时显著增加，称之为 ...

The CD4 + T cell dependence of vaccines with antigen-transduced DC has also been reported in other tumor models. 45,46 We believe that in our experimental system, the enhanced antitumor efficacy ...

宿主效应 cd4 + t 细胞是肿瘤消退的关键介质，但它们能否被过继转移的 cd8 + t 细胞激活尚不清楚。 此前有研究报道，过继转移产生白细胞介素 9（il-9）的细胞毒性 cd8 + t（tc9）细胞可实现对肿瘤生长的长期控制。 在本研究中发现，小鼠肿瘤特异性 tc9 细胞能通过招募并激活宿主效应 cd4 + t 细胞，来 ...

Twenty-eight patients (74%) received five DC vaccinations and completed the study protocol ... Vaccination led to the enrichment of circulating activated CD4+ T cells and the detection of ...

The first immunotherapy to use genetically engineered CD4 T-cells and targeting MAGE-A3 ... director of the Lombardi Comprehensive Cancer Center at Georgetown University, in Washington, DC, ...

The relationship between the timing of the initiation of antiretroviral therapy (ART) after infection with human immunodeficiency virus type 1 (HIV-1) and the recovery of CD4+ T-cell counts is unkn ...