College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China ...

Department of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110-749, South Korea ...

Most organic drugs contain one acid group, usually a carboxylic acid, -COOH, or one basic primary, secondary, or tertiary amino group, NC 1-3, [3,22,27,28,29] that determines the acid-base ...