Catastrophic macropinocytosis, also called methuosis, as a nonapoptotic cell death associated with cytoplasmic vacuolization, has gained increasing attention, largely because of its potential ...

Despite being mainly composed of terminally differentiated myocytes that cannot re-enter the cell cycle, the heart is not a postmitotic organ and maintains some capacity to form new parenchymal ...

Vacuole membrane protein 1 (VMP1) is an integral membrane protein that plays a pivotal role in cellular processes, particularly in the regulation of autophagy. Autophagy, a self-degradative mechanism, ...

Microscopically, there was hypertrophy of the myocardial fibers, with some swelling and perinuclear vacuolization. The thrombi and subendocardial areas were replaced by masses of fibrous tissue (Fig.

In addition, periglomerular and interstitial fibrosis, tubular dilatation and atrophy and vacuolization of tubular epithelium were noted, but no granulomas were seen and stains for fungi and ...

A 6-year-old boy was apparently well 4 months prior reporting to the clinic, when his parents noticed an asymptomatic, progressive change in the texture of his fingernails and toenails. They ...

Cholestasis in general is classified as either extrahepatic, where there is a mechanical obstruction to the main bile ducts, or intrahepatic, where such an obstructive lesion cannot be ...

The term dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders that are characterized by ventricular dilation and depressed myocardial performance in the absence of ...

The Asterisk (*) denotes mesenchymal cells from multiple sources. Figure 3. Expression patterns of Cx43 in human ESC–derived cardiomyocytes and neonatal rat ventricular myocytes. Images are of human ...

This important study addresses the idea that defective lysosomal clearance might be causal to renal dysfunction in cystinosis. With mostly solid data, the authors observe that restoring expression of ...